Lightweight block ciphers are primarily designed for resource constrained devices. However, due to service requirements of large-scale IoT networks and systems, the need for efficient software implementations can not be ruled out. A number of studies have compared software implementations of different lightweight block ciphers on a specific platform but to the best of our knowledge, this is the first attempt to benchmark various software implementations of a single lightweight block cipher across different programming languages and platforms in the cloud architecture. In this paper, we defined six lookup-table based software implementations for lightweight block ciphers with their characteristics ranging from memory to throughput optimized variants. We carried out a thorough analysis of the two costs associated with each implementation (memory and operations) and discussed possible trade-offs in detail. We coded all six types of implementations for three key settings (64, 80, 128 bits) of LED (a lightweight block cipher) in four programming languages (Java, C#, C++, Python). We highlighted the impact of choice relating to implementation type, programming language, and platform by benchmarking the seventy-two implementations for throughput and software efficiency on 32 & 64-bit platforms for two major operating systems (Windows & Linux) on Amazon Web Services Cloud. The results showed that these choices can affect the efficiency of a cryptographic primitive by a factor as high as 400.